Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism

A number of studies point at platelet monoamine oxidase (MAO) activity being reduced in alcoholics with a family history of drinking, this being a possible vulnerability marker for alcoholism. To test this hypothesis, we examined a group of recently detoxified alcoholics with high (n = 25) and low genetic loading for alcoholism (n = 28) and a group of healthy controls (n = 21). Clinical assessments were made using the SCID II interview for psychiatric disorders, the Family History Assessment Module and the Semi-Structural Assessment of Genetics in Alcoholism, a questionnaire especially designed for genetic studies. Platelet MAO activity with and without ethanol stimulation and the percentage of MAO activity with ethanol did not differ between groups. The only significant difference was a lower inhibition of MAO activity with ethanol in alcoholics both with and without a family history compared to controls. In patients with antisocial personality traits, platelet MAO activity was also not found to be different from other alcoholics. Our findings question the hypothesis of reduced platelet MAO activity to be a possible vulnerability marker for alcoholism. Copyright (C) 2000 S. Karger AG. Basel

A logic road from special relativity to general relativity

We present a streamlined axiom system of special relativity in first-order logic. From this axiom system we "derive" an axiom system of general relativity in two natural steps. We will also see how the axioms of special relativity transform into those of general relativity. This way we hope to make general relativity more accessible for the non-specialist

Electron correlation and short-range dynamics in attosecond angular streaking

We employ the R matrix with time-dependence method to study attosecond angular streaking of F−. Using this negative ion, free of long-range Coulomb interactions, we elucidate the role of short-range electron correlation effects in an attoclock scheme. Through solution of the multielectron time-dependent Schrödinger equation, we aim to bridge the gap between experiments using multielectron targets, and one-electron theoretical approaches. We observe significant negative offset angles in the photoelectron momentum distributions, despite the short-range nature of the binding potential. We show that the offset angle is sensitive to the atomic structure description of the residual F atom. We also investigate the response of co- and counter-rotating electrons, and observe an angular separation in their emissio

Interactions between vaccinia virus and sensitized macrophages in vitro

The action of peritoneal exudate cells (PEC) from normal and vaccinia virus infected mice on infectious vaccinia virus particles was investigatedin vitro. PEC from immune mice showed a significantly higher infectivity titre reduction (virus clearance, VC) than normal cells. This effect could be clearly attributed to the macrophage. Vaccinia virus multiplied in PEC from normal animals while there was no virus propagation in cells from immunized mice. The release of adsorbed or engulfed virus was reduced significantly in PEC from immunized animals. Anti-vaccinia-antibodies seem to activate normal macrophages to increased virus clearance. This stimulating effect was demonstrable only in the IgG fraction of the antiserum. The activity of macrophages from mice injected three times over a period of 14 days with vaccinia virus could be entirely blocked with anti-mouse-IgG, while PEC from mice injected one time six days previously were not inhibited

RMT: R-matrix with time-dependence. Solving the semi-relativistic, time-dependent Schrödinger equation for general, multi-electron atoms and molecules in intense, ultrashort, arbitrarily polarized laser pulses

RMT is a program which solves the time-dependent Schrödinger equation for general, multielectron atoms, ions and molecules interacting with laser light. As such it can be used to model ionization (single-photon, multiphoton and strong-field), recollision (high-harmonic generation, strong-field rescattering) and, more generally, absorption or scattering processes with a full account of the multielectron correlation effects in a time-dependent manner. Calculations can be performed for targets interacting with ultrashort, intense laser pulses of long wavelength and arbitrary polarization. Calculations for atoms can optionally include the Breit–Pauli correction terms for the description of relativistic (in particular, spin–orbit) effects

Are fossil groups a challenge of the Cold Dark Matter paradigm?

We study six groups and clusters of galaxies suggested in the literature to be `fossil' systems (i.e. to have luminous diffuse X-ray emission and a magnitude gap of at least 2 mag-R between the first and the second ranked member within half of the virial radius), each having good quality X-ray data and SDSS spectroscopic or photometric coverage out to the virial radius. The poor cluster AWM4 is clearly established as a fossil system, and we confirm the fossil nature of four other systems (RXJ1331.5+1108, RXJ1340.6+4018, RXJ1256.0+2556 and RXJ1416.4+2315), while the cluster RXJ1552.2+2013 is disqualified as fossil system. For all systems we present the luminosity functions within 0.5 and 1 virial radius that are consistent, within the uncertainties, with the universal luminosity function of clusters. For the five bona fide fossil systems, having a mass range 2x10^13-3x10^14 M_Sun, we compute accurate cumulative substructure distribution functions (CSDFs) and compare them with the CSDFs of observed and simulated groups/clusters available in the literature. We demonstrate that the CSDFs of fossil systems are consistent with those of normal observed clusters and do not lack any substructure with respect to simulated galaxy systems in the cosmological LambdaCDM framework. In particular, this holds for the archetype fossil group RXJ1340.6+4018 as well, contrary to earlier claims.Comment: Accepted for publication on MNRAS. Minor changes in sections 2.1 and 6. 13 pages, 4 eps figure

Testing adiabatic contraction of dark matter in fossil group candidates

We present deep XMM observations and ESO WFI optical imaging of two X-ray-selected fossil group candidates, RXCJ0216.7-4749 and RXCJ2315.7-0222. Using the X-ray data, we derive total mass profiles under the hydrostatic equilibrium assumption. The central regions of RXCJ0216.7-4749 are found to be dominated by an X-ray bright AGN, and although we derive a mass profile, uncertainties are large and the constraints are significantly weakened due to the presence of the central source. The total mass profile of RXCJ2315.7-0222 is of high quality, being measured in fifteen bins from [0.075 - 0.75]R500 and containing three data points interior to 30 kpc, allowing comprehensive investigation of its properties. We probe several mass models based on the standard NFW profile or on the Sersic-like model recently suggested by high-resolution N-body simulations. We find that the addition of a stellar component due to the presence of the central galaxy is necessary for a good analytical model fit. In all mass profile models fitted, the mass concentration is not especially high compared to non-fossil systems. In addition, the modification of the dark matter halo by adiabatic contraction slightly improves the fit. However, our result depends critically on the choice of IMF used to convert galaxy luminosity to mass, which leads to a degeneracy between the central slope of the dark matter profile and the normalisation of the stellar component. While we argue on the basis of the range of M_*/L_R ratios that lower M_*/L_R ratios are preferred on physical grounds and that adiabatic contraction has thus operated in this system, better theoretical and observational convergence on this problem is needed to make further progess.Comment: to appear in Astronomy & Astrophysics, 16 pages, 24 figure

How Noisy Adaptation of Neurons Shapes Interspike Interval Histograms and Correlations

Channel noise is the dominant intrinsic noise source of neurons causing variability in the timing of action potentials and interspike intervals (ISI). Slow adaptation currents are observed in many cells and strongly shape response properties of neurons. These currents are mediated by finite populations of ionic channels and may thus carry a substantial noise component. Here we study the effect of such adaptation noise on the ISI statistics of an integrate-and-fire model neuron by means of analytical techniques and extensive numerical simulations. We contrast this stochastic adaptation with the commonly studied case of a fast fluctuating current noise and a deterministic adaptation current (corresponding to an infinite population of adaptation channels). We derive analytical approximations for the ISI density and ISI serial correlation coefficient for both cases. For fast fluctuations and deterministic adaptation, the ISI density is well approximated by an inverse Gaussian (IG) and the ISI correlations are negative. In marked contrast, for stochastic adaptation, the density is more peaked and has a heavier tail than an IG density and the serial correlations are positive. A numerical study of the mixed case where both fast fluctuations and adaptation channel noise are present reveals a smooth transition between the analytically tractable limiting cases. Our conclusions are furthermore supported by numerical simulations of a biophysically more realistic Hodgkin-Huxley type model. Our results could be used to infer the dominant source of noise in neurons from their ISI statistics